For me the saddest anime death would have to be [spoiler]Kenshin Himura's[/spoiler] from Samurai X.Instead of having a honorable death in battle he died of leprosy.I mean how lame is that?!The only good thing about him not dying in battle is he was still known as the best.But he could have been in battle,gotten wounded,killed the bad guy,and then died.But thats just my opinion.