Ouran High School Host Club - Technically a romance, but I love it for it's comedy and the difficulties the characters face, from Tamaki deciding his role in Haruhi's life, to Honey not getting candy. Also has one of my favorite girl characters of all time (drumroll). Haruhi! She has such a lackluster and uncaring attitude that is very amusing, in contrast to Tamaki's over dramatic personality, Kyoya's superior money loving self, Mori's silent strength, Honey's little kid over-sweetness, Kaoru's somewhat sensitive almost feminine personality, and Hikaru's thoughtlessness. The anime is also lovely, though the ending is totally different. I love both.
Fruits Basket - At first it seems like a cheery story of a girl finding love, but so many crazy twists happen along the way that it ends up much different than what you think. The sinister undertones throughout ar contrasted completely by Tohru, who, despite everything that happens is as cheerful as can be. My favorite characters are Tohru's friends Hanajima and Uotani.
Naruto - Though the series has drawn on way too long, and it seems that Kishimoto is running low on character ideas, something about it keeps me reading. I still have to find out what's going to happen to Naruto, if he will be hokage, will there be a happy ending, or will Sasuke mess everything up for everyone.
Fushigi Yugi: Genbu Kaiden - A fantasy adventure where the protagonist is thrown into the past. Sounds like Inuyasha, right? But this prequel to The Mysterious Play turns the allies into specific people with strange powers that Takiko must find, none of whom seem particularly inclined to help her, especially after they discover a twist to the prophecy. But without them, she can't save their world.
Deathnote - Sinister horror, where the protagonist can be the bad guy or the good guy, depending on who you ask.. Deathnote delves into the minds of two very intelligent young men as they chase each other in circles, trying to discover who the other is so that they can eliminate him for the "greater good". One is manipulated by a shinigami, while the other works with the police to catch the "all powerful" Kira.